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NINDS Custom Collection II
The NINDS Custom Collection (1040 compounds)
This collection was prepared to meet the needs of the multi-center screening program launched by the NIH/NINDS in 2001 in the search for new therapies in neurodegenerative diseases. We began the design of this collection by using GenPlus as our base, and added selected CNS active compounds and heat shock modifiers to broaden the therapeutic scope. The collection and the screening program were resounding successes. We have since modified the content of the collection by replacing the numerous controlled substances which had been included, with newer drug representatives and reissued it as the NINDS-II Collection. In 2005, this collection has formed the basis of another multi-center screening program for the combined NIH/JDRF (Juvenile Diabetes Research Foundation) project in the search for new therapeutic approaches in Diabetes..
References to the use of the NINDS Collection:
- J Heemskerk, AJ Tobin and B Ravina, From Chemical to Drug: Neurodegeneration Drug Screening and the Ethics of Clinical Trials, Nature Neuroscience (Suppl) 5:1027 (2002);
- A Abbott, Neurologists strike gold in drug screen effort, Nature 417:109 (2002);
- F Piccioni, BR Roman, KH Fischbeck and JP Taylor, A Screen For Drugs That Protect Against The Cytotoxicity Of Polyglutamine-Expanded Androgen Receptor, Hum Mol Genetics 13:437 (2004) 13:437 (2004)
- JD Rothstein, S Patel, MR Regan, C Haenggeli, YH Huang, DE Bergles, L Jin, M Dykes Hoberg, S Vidensky, DS Chung, SV Toan, LI Bruijn, Z Su, P Gupta and PB Fisher, ß-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression, Nature 433:73 (2005).
.xls file .sdf file (zipped)
To search for a specific compound press Ctrl+F in Internet Explorer.
ACACETIN
ACEBUTOLOL HYDROCHLORIDE
ACECLIDINE HYDROCHLORIDE
ACEMETACIN
ACETAMINOPHEN
ACETAMINOSALOL
ACETANILIDE
ACETARSOL
ACETAZOLAMIDE
ACETOHYDROXAMIC ACID
ACETRIAZOIC ACID
ACETYL TYROSINE ETHYL ESTER
ACETYLCARNITINE
ACETYLCHOLINE
ACETYLCYSTEINE
ACETYLGLUCOSAMINE
ACETYLGLUTAMIC ACID
ACETYL-L-LEUCINE
ACETYLPHENYLALANINE
ACETYLSEROTONIN
ACETYLTRYPTOPHAN
ACEXAMIC ACID
ACIVICIN
ACLACINOMYCIN A1
ACONITINE
ACRIFLAVINIUM HYDROCHLORIDE
ACRISORCIN
ACTINONIN
ACYCLOVIR
ADENOSINE PHOSPHATE
ADENOSINE
ADRENALINE BITARTRATE
AESCULIN
AJMALINE
AKLAVINE HYDROCHLORIDE
ALANYL-dl-LEUCINE
ALANYL-dl-PHENYLALANINE
ALAPROCLATE
ALBENDAZOLE
ALBUTEROL
ALEXIDINE HYDROCHLORIDE
ALLANTOIN
ALLOPURINOL
ALMOTRIPTAN
ALOIN
ALPRENOLOL
ALTRETAMINE
ALVERINE CITRATE
AMANTADINE HYDROCHLORIDE
AMBROXOL HYDROCHLORIDE
AMCINONIDE
AMIKACIN SULFATE
AMILORIDE HYDROCHLORIDE
3-AMINOBENZAMIDE
gamma-AMINOBUTYRIC ACID
AMINOCAPROIC ACID
N- (2-AMINOETHYL)-4-CHLOROBENZAMIDE (RO-16-6491)
AMINOGLUTETHIMIDE
AMINOHIPPURIC ACID
AMINOHYDROXYBUTYRIC ACID
AMINOLEVULINIC ACID HYDROCHLORIDE
AMINOPHENAZONE
3-AMINOPROPANESULPHONIC ACID
AMINOPYRIDINE
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE
AMINOTHIAZOLE
AMIODARONE HYDROCHLORIDE
AMIPRILOSE
AMITRIPTYLINE HYDROCHLORIDE
AMLODIPINE BESYLATE
AMODIAQUINE DIHYDROCHLORIDE
AMOXEPINE
AMOXICILLIN
AMPICILLIN SODIUM
AMPROLIUM
AMRINONE
AMYGDALIN
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